技術

革新的なペプチド合成基盤技術が医薬品の高付加価値化と経済性の両立を可能にします

Molecular Hiving™

A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems.

Kazuhiro Chiba,* Yusuke Kono, Shokaku Kim, Kohsuke Nishimoto, Yoshikazu Kitano, Masahiro Tada
Chemical Communications 2002, 1766–1767.

Synthesis of hydrophobic phase-tagged prolyl peptides featuring rapid reaction/separation.

Kazuhiro Chiba,* Mari Sugihara, Kazumi Yoshida, Yuzuru Mikami, Shokaku Kim.
Tetrahedron 2009, 65, 8014–8020.

Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions.

Motoyuki Iijima, Yuzuru Mikami, Tomohiko Yoshioka, Shokaku Kim, Hidehiro Kamiya, Kazuhiro Chiba*
Langmuir 2009, 25, 11043–11047.

A practical solution-phase synthesis of an antagonistic peptide of TNF-a based on hydrophobic tag strategy.

Gegen Tana, Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba*
Chemical Communications 2010, 46, 8219–8221.

Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin.

Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba*
Bioorganic Medicinal Chemistry Letters 2011, 21, 4476–4479.

Soluble-Support-Assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation.

Shingo Kitada, Masahito Takahashi, Yusuke Yamaguchi, Yohei Okada, Kazuhiro Chiba*
Organic Letters 2012, 14, 5960–5963.

Tag-Assisted Liquid-Phase Peptide Synthesis using Hydrophobic Benzyl Alcohols as Supports.

Yohei Okada, Hideaki Suzuki, Takashi Nakae, Shuji Fujita, Hitoshi Abe, Kazuo Nagano, Toshihide Yamada, Nobuyoshi Ebata, Shokaku Kim, Kazuhiro Chiba*
The Journal of Organic Chemistry 2013, 78, 320–327.

Total synthesis of a-conotoxin MII using a soluble-tag-assisted method.

Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba*
Tetrahedron 2013, 69, 2555–2559.

Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B.

Yuko Fujita, Shuji Fujita, Yohei Okada, Kazuhiro Chiba*
Organic Letters 2013, 15, 1155–1157.

Phase-transfer-mediated electrochemical reaction: anodic disulfide bond formation under biphasic condition.

Masahito Takahashi, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba*
Tetrahedron Letters 2014, 55, 3622–3624.

Total Synthesis of Elastin Peptide Using High Pressure-Liquid Phase Synthesis Assisted by a Soluble Tag Strategy.

Yohei Okada, Shoichi Hosoya, Hidenobu Suzuki, Kazuhiro Chiba*
Organic Letters 2014, 16, 6448–6451.

Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510.

Emiko Matsumoto, Yuko Fujita, Yohei Okada, Esko I. Kauppinen, Hidehiro Kamiya, Kazuhiro Chiba*
Journal of Peptide Science 2015, 21, 691–695.

Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis.

Yohei Okada, Hiroki Wakamatsu, Masae Sugai, Esko I. Kauppinen, Kazuhiro Chiba*
Organic Letters 2015, 17, 4264–4267.

Peptune™

A disulfide bond-replacement strategy enables the efficient design of artificial therapeutic peptides.

Kazuhiro Aoki, Miki Maeda, Takashi Nakae, Yohei Okada, Keiichi Ohya, Kazuhiro Chiba*
Tetrahedron 2014, 70, 7774–7779.

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