Molecular Hiving™
High Quality Environmentally friendly 
High cost-efficiency
Molecular Hiving™
High Quality
Environmentally friendly
High cost-efficiency
High Quality
In-process test can be performed every step of the elongation process. The sample for the in-process test can be obtained easily by direct sampling from the reaction mixture. The test uses UHPLC and TLC and we can find impurities at 0.05% detection level. Resulted in the monitoring of the product in every step of the elongation steps, the best protocol of the process can be prepared and we can obtain high purity crude of the target peptide.

Yohei Okada, Rico Takasawa, Daisuke Kubo, Natsumi Iwanaga, Shuji Fujita, Kosuke Suzuki, Hideaki Suzuki, Hidehiro Kamiya and Kazuhiro Chiba*
Organic Process Research & Development 2019, 23, 11, 2576-2581.

Environmentally friendly
Molecular Hiving™ controls residual solvents according to ICH Q3C guideline and furthermore select CMR free organic solvents for the elongation process according to ” Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products” . Molecular Hiving™ uses less quantities of raw materials and solvents than the traditional peptide synthesis.
Solvent for cosmetic products
Molecular Hiving™ Standard Solvents
Preferred Usable Undesirable Banned
1-Butanol 2-propanol 1,2-Diethoxyethane 2-Methoxyethyl ether(Diglyme)
1-Propanol(pref.over2-prop) Acetonitrile Anisol Benzene
2-Butanol Cyclohexane Cellosolves(Me- and Et-) Carbon tetra Chloride
2-Methyl THF Cyclohexanon Chlorobenzene Chloroform
Acetone Di-isopropyl ether Dichloromethane(close to banned) Ethylenedichloride
Amylacetate DMSO Diethyl ether(close to banned)  
Benzyl alcohol Ethyl acetate Dimethoxyethane(Glyme)  
Cyclopentylmethylether(CPME) Heptane Dimethyl acetamide  
Ethanol(pref.overMethanol),inc., Isooctane Dimethyl formamide  
Ethyl lactate Methanol Dioxane(close to banned)  
Isoamyl alcohol Methyl ethyl ketone Ethyl benzene  
Isobutyl acetate Methyl isobutyl keone(MIBK) Ethylene glycol  
Isopropyl acetate Methyl acetate Hexane(s)(close to banned)  
N-Buthylacetate Methylcyclohexane Methylformate(close to banned)  
Water t-Butanol N-Ethyl Pyrrolidone(preferred over NMP)  
  t-Butyl Ethyl ether N-Methyl Pyrrolidone(NMP)  
  t-Butyl Methyl ether Pentane  
  t-Butyl Methyl ether THF
  t-Butyl Methyl ether Toluene
Xylene(s) Trifluorotoluene(close to banned)
Solvent for cosmetic product Molecular Hiving™ Standard Solvents Preferred 1-Butanol 1-Propanol(pref.over2-prop) 2-Butanol 2-Methyl THF Acetone Amylacetate Benzyl alcohol Cyclopentylmethylether(CPME) Ethanol(pref.overMethanol),inc., Ethyl lactate Isoamyl alcohol Isobutyl acetate Isopropyl acetate N-Buthylacetate Water
Usable Molecular Hiving™ Standard Solvents 2-propanol Acetonitrile Cyclohexane Cyclohexanon Di-isopropyl ether CDMSO Ethyl acetate Heptane Isooctane Methanol Methyl ethyl ketone Methyl isobutyl keone(MIBK) Methyl acetate Methylcyclohexane t-Butanol t-Butyl Ethyl ether t-Butyl Methyl ether Xylene(s)
Undesirable 1,2-Diethoxyethane Anisol Chlorobenzene Dichloromethane(close to banned) Diethyl ether(close to banned) Dimethoxyethane(Glyme) Dimethyl acetamide Dimethyl formamide Dioxane(close to banned) Ethyl benzene Ethylene glycol Hexane(s)(close to banned) Methylformate(close to banned) N-Ethyl Pyrrolidone(preferred over NMP) N-Methyl Pyrrolidone(NMP) Pentane THF Toluene Trifluorotoluene(close to banned)
Banned 2-Methoxyethyl ether(Diglyme) Benzene Carbon tetra Chloride Chloroform Ethylenedichloride
Raw Materials Molecular Hiving Traditional Method
Organic Solvents 1/10 ※1 1
Amino acid & Coupling Reagents 1/4 ※2 1
※1Depends on AA number and sequence
※2Internal results
High cost-efficiency

Cost-efficient process of Molecular Hiving™ conducts the one-pot method of elongation using minimum quantities of raw materials, by high yield, high purity, and high performance of the operation.

•Raw material quantity is low.

•Reaction and work-up operation time is short.

•Special and new facility is not required.

•Batch size is high.