Molecular Hiving™ is a Tag-assisted Liquid-Phase Peptide Synthesis technology developed by Professor Kazuhiro Chiba at Tokyo University of Technology and Agriculture. Molecular Hiving™ technology uses a hydrophobic tag, a simple chemical structure but having variable function by introducing variable function groups into aromatic ring, e.g. hydrophobic benzyl alcohol and amine as shown below. When the target peptide has carboxylate at C-terminus, the tag is 1, and amide, the tag is 2. Both of tag 1 and 2 can be removed by global deprotection condition after the completion of elongation. Tag acts the same as the resin of solid-phase peptide synthesis, however, the intermediates can be solved and the reaction mixture is homogeneous. The technology needs no questions of scaling up and the one-pot procedure needs only one reactor for the elongation process.