Technology Outline

Core technology

Molecular Hiving™
Molecular Hiving™ is a Tag-assisted Liquid-Phase Peptide Synthesis technology developed by Professor Kazuhiro Chiba at Tokyo University of Technology and Agriculture. Molecular Hiving™ technology uses a hydrophobic tag, a simple chemical structure but having variable function by introducing variable function groups into aromatic ring, e.g. hydrophobic benzyl alcohol and amine as shown below. When the target peptide has carboxylate at C-terminus, the tag is 1, and amide, the tag is 2. Both of tag 1 and 2 can be removed by global deprotection condition after the completion of elongation. Tag acts the same as the resin of solid-phase peptide synthesis, however, the intermediates can be solved and the reaction mixture is homogeneous. The technology needs no questions of scaling up and the one-pot procedure needs only one reactor for the elongation process.
Drawing
What is peptide?
Drawing
Drawing
Protein Peptide Amino acid
Amino acid numbers 50 ~ 100,000+ 2 ~ 49 1
Type of Amino acid Natural Natural, non-Natural 20 of Natural・non-Natural
Molecular Wight 150,000+ 170 ~ 3,000+ 90 ~ 200+
Use Essential nutrients
Antibody drugs
Medicinal drug
Cosmetics
Functional food
Food additives
Supplement
Raw material of peptides
Manufacturing Biological Synthesis Enzymatic degradation of protein
Gene recombination
Chemical synthesis
Fermentation
Chemical synthesis
Protein
Amino acid numbers 50 ~ 100,000+
Type of Amino acid Natural
Molecular Wight 150,000+
Use Essential nutrients
Antibody drugs
Manufacturing Biological Synthesis
Peptide
Amino acid numbers 2 ~ 49
Type of Amino acid Natural, non-Natural
Molecular Wight 170 ~ 3,000+
Use Medicinal drug
Cosmetics
Functional food
Manufacturing Gene recombination
Chemical synthesis
Amino acid
Amino acid numbers 1
Type of Amino acid 20 of Natural・non-Natural
Molecular Wight 90 ~ 200+
Use Food additives
Supplement
Raw material of peptides
Manufacturing Fermentation
Chemical synthesis
Peptide is formed by degradation of protein or by synthesis of some amino acids and includes 2 to 49 amino acids. Peptide uses for functional food, cosmetics, and medicinal drugs which recently get attention as medium molecular drug as well as oligonucleotide. Peptides drug have been developed for metabolism, cancers, infections, CNS, and rare diseases. Antibody drug positions high molecular drug and is expensive. On the other hand, peptide can be manufactured by chemical synthesis and resulted to provide the reasonable price in the market. Jitsubo provides peptides manufactured by our core technology with environment friendly and safe raw materials to the market.
PAGE TOP