コア技術 – 関連論文

Molecular Hiving™

関連論文

Molecular Hiving™
Improved Tag-Assisted Liquid-Phase Peptide Synthesis:
Application to the Synthesis of the Bradykinin Receptor Antagonist Icatibant Acetate.
Yohei Okada, Rico Takasawa, Daisuke Kubo, Natsumi Iwanaga, Shuji Fujita, Kosuke Suzuki, Hideaki Suzuki, Hidehiro Kamiya and Kazuhiro Chiba* Organic Process Research & Development 2019, 23, 11, 2576-2581.
Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis.
Yohei Okada, Hiroki Wakamatsu, Masae Sugai, Esko I. Kauppinen, Kazuhiro Chiba* Organic Letters 2015, 17, 4264–4267
Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510.
Emiko Matsumoto, Yuko Fujita, Yohei Okada, Esko I. Kauppinen, Hidehiro Kamiya, Kazuhiro Chiba* Journal of Peptide Science 2015, 21, 691–695
Total Synthesis of Elastin Peptide Using High Pressure-Liquid Phase Synthesis Assisted by a Soluble Tag Strategy.
Yohei Okada, Shoichi Hosoya, Hidenobu Suzuki, Kazuhiro Chiba* Organic Letters 2014, 16, 6448–6451
Phase-transfer-mediated electrochemical reaction: anodic disulfide bond formation under biphasic condition.
Masahito Takahashi, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba* Tetrahedron Letters 2014, 55, 3622–3624
Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B.
Yuko Fujita, Shuji Fujita, Yohei Okada, Kazuhiro Chiba* Organic Letters 2013, 15, 1155–1157
Total synthesis of a-conotoxin MII using a soluble-tag-assisted method.
Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba* Tetrahedron 2013, 69, 2555–2559
Tag-Assisted Liquid-Phase Peptide Synthesis using Hydrophobic Benzyl Alcohols as Supports.
Yohei Okada, Hideaki Suzuki, Takashi Nakae, Shuji Fujita, Hitoshi Abe, Kazuo Nagano, Toshihide Yamada, Nobuyoshi Ebata, Shokaku Kim, Kazuhiro Chiba* The Journal of Organic Chemistry 2013, 78, 320–327
Soluble-Support-Assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation.
Shingo Kitada, Masahito Takahashi, Yusuke Yamaguchi, Yohei Okada, Kazuhiro Chiba* Organic Letters 2012, 14, 5960–5963
Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin.
Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba* Bioorganic Medicinal Chemistry Letters 2011, 21, 4476–4479
A practical solution-phase synthesis of an antagonistic peptide of TNF-a based on hydrophobic tag strategy.
Gegen Tana, Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba* Chemical Communications 2010, 46, 8219–8221
Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions.
Motoyuki Iijima, Yuzuru Mikami, Tomohiko Yoshioka, Shokaku Kim, Hidehiro Kamiya, Kazuhiro Chiba* Langmuir 2009, 25, 11043–11047
Synthesis of hydrophobic phase-tagged prolyl peptides featuring rapid reaction/separation.
Kazuhiro Chiba,* Mari Sugihara, Kazumi Yoshida, Yuzuru Mikami, Shokaku Kim. Tetrahedron 2009, 65, 8014–8020
A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems.
Kazuhiro Chiba,* Yusuke Kono, Shokaku Kim, Kohsuke Nishimoto, Yoshikazu Kitano, Masahiro Tada Chemical Communications 2002, 1766–1767
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