Publications

Molecular Hiving™

Improved Tag-Assisted Liquid-Phase Peptide Synthesis:
Application to the Synthesis of the Bradykinin Receptor Antagonist Icatibant Acetate.

Yohei Okada, Rico Takasawa, Daisuke Kubo, Natsumi Iwanaga, Shuji Fujita, Kosuke Suzuki, Hideaki Suzuki, Hidehiro Kamiya and Kazuhiro Chiba* Organic Process Research & Development 2019, 23, 11, 2576-2581.

Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis.

Yohei Okada, Hiroki Wakamatsu, Masae Sugai, Esko I. Kauppinen, Kazuhiro Chiba* Organic Letters 2015, 17, 4264–4267

Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510.

Emiko Matsumoto, Yuko Fujita, Yohei Okada, Esko I. Kauppinen, Hidehiro Kamiya, Kazuhiro Chiba* Journal of Peptide Science 2015, 21, 691–695

Total Synthesis of Elastin Peptide Using High Pressure-Liquid Phase Synthesis Assisted by a Soluble Tag Strategy.

Yohei Okada, Shoichi Hosoya, Hidenobu Suzuki, Kazuhiro Chiba* Organic Letters 2014, 16, 6448–6451

Phase-transfer-mediated electrochemical reaction: anodic disulfide bond formation under biphasic condition.

Masahito Takahashi, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba* Tetrahedron Letters 2014, 55, 3622–3624

Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B.

Yuko Fujita, Shuji Fujita, Yohei Okada, Kazuhiro Chiba* Organic Letters 2013, 15, 1155–1157

Total synthesis of a-conotoxin MII using a soluble-tag-assisted method.

Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba* Tetrahedron 2013, 69, 2555–2559

Tag-Assisted Liquid-Phase Peptide Synthesis using Hydrophobic Benzyl Alcohols as Supports.

Yohei Okada, Hideaki Suzuki, Takashi Nakae, Shuji Fujita, Hitoshi Abe, Kazuo Nagano, Toshihide Yamada, Nobuyoshi Ebata, Shokaku Kim, Kazuhiro Chiba* The Journal of Organic Chemistry 2013, 78, 320–327

Soluble-Support-Assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation.

Shingo Kitada, Masahito Takahashi, Yusuke Yamaguchi, Yohei Okada, Kazuhiro Chiba* Organic Letters 2012, 14, 5960–5963

Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin.

Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba* Bioorganic Medicinal Chemistry Letters 2011, 21, 4476–4479

A practical solution-phase synthesis of an antagonistic peptide of TNF-a based on hydrophobic tag strategy.

Gegen Tana, Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba* Chemical Communications 2010, 46, 8219–8221

Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions.

Motoyuki Iijima, Yuzuru Mikami, Tomohiko Yoshioka, Shokaku Kim, Hidehiro Kamiya, Kazuhiro Chiba* Langmuir 2009, 25, 11043–11047

Synthesis of hydrophobic phase-tagged prolyl peptides featuring rapid reaction/separation.

Kazuhiro Chiba,* Mari Sugihara, Kazumi Yoshida, Yuzuru Mikami, Shokaku Kim. Tetrahedron 2009, 65, 8014–8020

A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems.

Kazuhiro Chiba,* Yusuke Kono, Shokaku Kim, Kohsuke Nishimoto, Yoshikazu Kitano, Masahiro Tada Chemical Communications 2002, 1766–1767